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Subjects. Twenty seven patients with PWS and 21 of their siblings participated in the study of both functional changes in the brain and neuroanatomical variability across their lifespan (43,44).Among them, 21 children with PWS (10 girls, 11 boys; mean age, 7.3 ±9.3years) and 18 healthy siblings of these patients with PWS (control group; 10 girls, 8 boys, p = 0.632; mean age, 11.1 ±8.4years